Upon first launch of Desktop Studio just after installation you’ll be presented with error message: “Object reference not set to an instance of an object. reload the snap-in to retry.”

Solution1:

Cause: Because “CitrixConfigurationService” service is NOT running on your system.  In the eventvwr you’ll notice that reason why this service failing to startup.  The most probable cause is that “This computer is not joined to a domain; these services cannot be run outside of a domain.”

Log Name:      Application
Source:        CitrixConfigurationService
Date:          7/24/2013 11:02:02 AM
Event ID:      1016
Task Category: None
Level:         Error
Keywords:      Classic
User:          N/A
Computer:      TESTSRV01
Description:
This computer is not joined to a domain; these services cannot be run outside of a domain.

Fix: Join your computer to a domain.

Solution2:

You have either not installed the x86 SQL Shared Management objects or you have a missing registry key.

There’s two ways that you can fix this. Either install the x86 SQL Shared Management Objects from the XenDesktop CD. This is located in

\Support\SharedManagementObjects\x86

Or create the missing registry key that Desktop Studio is looking for. Copy the below steps into a .reg file and run it
Windows Registry Editor Version 5.00

[HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\Microsoft\Microsoft SQL Server\SharedManagementObjects\CurrentVersion]

“Version”=”10.50.1600.1”

“CSDVersionNumber”=dword:00000000

“PatchLevel”=”10.50.1600.1”